Agilent announced it had completed the spin-off of its electronic measurement business, Keysight Technologies. On November 1, the formal separation of Agilent and Keysight Technologies was completed. On October 14, 2014, the company announced that it is exiting its Nuclear Magnetic Resonance business. The life sciences company retained the Agilent name and the electronic measurement company was called Keysight Technologies.

On September 19, 2013, Agilent announced its decision to separate into two publicly traded companies: Agilent, a life sciences, diagnostics, and applied markets company, and an electronic measurement company. On May 17, 2012, Agilent agreed to buy Dako, a Danish cancer diagnostics company, for $2.2 billion, to expand its presence in the life sciences industry. Agilent announced it would increase its life sciences engagement through the acquisition of Halo Genomics, based in Uppsala, Sweden, which was involved in next-generation sequencing technology development. In 2011, the company, along with the University of California, Davis, announced that it would be establishing the 'Davis Millimeter Wave Research Center'. The product lines affected included the automated optical inspection, solder paste inspection, and automated X-ray products in 2004. In 2009, Agilent announced the closure of a subsection of its Test & Measurement division. Agilent listed the new company as Verigy on NASDAQ in mid-2006. Lumileds originally started as Hewlett-Packard's optoelectronics division.ДЄlso in August 2005, Agilent announced a plan to divest its semiconductor test business, composed of both the system-on-chip and memory test market areas. After purchasing Broadcom Corporation in 2016, Avago changed its name to Broadcom Limited.ДЄlso in August 2005, Agilent sold its 47% stake in the light-emitting diode manufacturer Lumileds to Philips for $1 billion. The group operated as a private company, Avago Technologies, until August 2009, when it was brought public in an IPO.

This move was part of a broad effort to concentrate 'on the test-and-measurement business at its historic core,' and would entail termination of about 1,300 of the company's 28,000 employees. In August 2005, Agilent announced the sale of its business which produced semiconductor integrated circuits (known as 'chips') for consumer and industrial uses to Kohlberg Kravis Roberts and Silver Lake Partners for $2.66 billion. HP Medical Products had been the second oldest part of Hewlett-Packard, acquired in the 1950s. In 2001, in midst of this downsizing, Agilent sold its health care and medical products organization to Philips Medical Systems, and was noted as having a valuation of about $11 billion. These poor economic conditions prompted large reductions in force from a headcount in 1999 of 35,000, which had risen to 48,000 by May 2001, it had by early 2003 cut 18,500 positions. The downturn also struck sales in the communications and semiconductor markets, where orders amounting to $500 million were canceled by buyers. In the early 2000s, 'economic uncertainty' depressed demand for Agilent's products, including slow sales of health care products to hospitals in the United States, which accounted for 60% of the company's revenue at the time. The Agilent spin-off was accompanied by an initial public offering which raised $2.1 billion, setting a record at the time. The starburst logo was selected to reflect 'a burst of insight' (or 'spark of insight') and the name 'Agilent' aimed to invoke the notion of agility as a trait of the new firm. The company's launch slogan was 'Innovating the HP Way', which capitalized on the strong HP corporate culture. The split was predicated on the difficulty of growing HP's revenue stream and on the competitive vigor of smaller, more agile competitors. Agilent Technologies headquarters lobby in Santa Clara, CaliforniaДЄgilent Technologies was created in 1999 by the spin-off of Hewlett-Packard's (HP's) 'Medical Products and Instrument Group', including instrumentation and chemical analysis, electronic components, and medical equipment product lines.

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